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1

Characterisation and biological activity of Glu3 amino acid substituted GIP receptor antagonists

Victor A. Gault, Kerry Hunter, Nigel Irwin, Brian D. Green, Brett Greer, Patrick Harriott, Finbarr P.M. O’Harte, Peter R. Flatt

Journal:

Archives of Biochemistry and Biophysics

Year:

2007

Language:

english

File:

PDF, 289 KB

english, 2007

2

Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic (ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1–39)amide

Nigel Irwin, Paula L. McClean, Roslyn S. Cassidy, Finbarr P. M. O'Harte, Brian D. Green, Victor A. Gault, Patrick Harriott, Peter R. Flatt

Journal:

Diabetes/Metabolism Research and Reviews

Year:

2007

Language:

english

File:

PDF, 153 KB

english, 2007

3

Evaluation of Some Fluorogenic Substrates for Continuous Assay of Aminopeptidase P

Susan J. Hawthorne, Patrick Harriott, Jaeseung Lim, Anthony J. Turner, Brian Walker, Carvell H. Williams

Journal:

Analytical Biochemistry

Year:

1997

Language:

english

File:

PDF, 117 KB

english, 1997

4

The Synthesis and Utilization of 2,4-Dinitrophenyl-Labeled Irreversible Peptidyl Diazomethyl Ketone Inhibitors

Susan J. Hawthorne, Maurice Pagano, Patrick Harriott, David W. Halton, Brian Walker

Journal:

Analytical Biochemistry

Year:

1998

Language:

english

File:

PDF, 248 KB

english, 1998

5

Synthesis, structure and complexing capabilities of N,N′,N′′,N′′′-tetrakis(3-hydroxypropyl)cyclam

Philip J. Davies, Max R. Taylor, Kevin P. Wainwright, Patrick Harriott, Paul A. Duckworth

Journal:

Inorganica Chimica Acta

Year:

1996

Language:

english

File:

PDF, 630 KB

english, 1996

6

Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl α-keto aldehydes (glyoxals)

John F. Lynas, Patrick Harriott, Adrienne Healy, M.Anthony McKervey, Brian Walker

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 279 KB

english, 1998

7

Toxicity of non-Aβ component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of β-sheet structure and fibrils

Angela M. Bodles, David J. S. Guthrie, Patrick Harriott, Pamela Campbell, G. Brent Irvine

Journal:

Year:

2000

Language:

english

File:

PDF, 884 KB

english, 2000

8

The synthesis of some peptides related to the amyloid β peptide 25–35: Use ofN-(2-hydroxy-4-methoxybenzyl) protection

Omar M. A. El-Agnaf, Patrick Harriott, David J. S. Guthrie, G. Brent Irvine, Brian Walker

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1994

Language:

english

File:

PDF, 414 KB

english, 1994

9

Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25–35) are dependent on stimulation-protocol and genetic background

Simon Gengler, Victor A. Gault, Patrick Harriott, Christian Hölscher

Journal:

Experimental Brain Research

Year:

2007

Language:

english

File:

PDF, 485 KB

english, 2007

10

Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide

Nigel Irwin, Gillian C. Clarke, Brian D. Green, Brett Greer, Patrick Harriott, Victor A. Gault, Finbarr P.M. O’Harte, Peter R. Flatt

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 765 KB

english, 2006

11

Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease

Paula L. McClean, Victor A. Gault, Patrick Harriott, Christian Hölscher

Journal:

European Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 479 KB

english, 2010

12

Beneficial effects of sub-chronic activation of glucagon-like peptide-1 (GLP-1) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice

Nigel Irwin, Paula L. McClean, Patrick Harriott, Peter R. Flatt

Journal:

Experimental Gerontology

Year:

2007

Language:

english

File:

PDF, 143 KB

english, 2007

13

Development of laminin receptor agonists: identification of important functional residues by alanine scanning

William N Scott, Neil V McFerran, Patrick Harriott, Brian Walker, John Nelson

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

2000

Language:

english

File:

PDF, 778 KB

english, 2000

14

The N-terminal region of non-Aβ component of Alzheimer's Disease amyloid is responsible for its tendency to assume β-sheet and aggregate to form fibrils

Omar M. A. El-Agnaf, Angela M. Bodles, David J. S. Guthrie, Patrick Harriott, G. Brent Irvine

Journal:

Year:

1998

Language:

english

File:

PDF, 458 KB

english, 1998

15

Characterization of the Cellular and Metabolic Effects of a Novel Enzyme-Resistant Antagonist of Glucose-Dependent Insulinotropic Polypeptide

Victor A. Gault, Finbarr P.M. O'Harte, Patrick Harriott, Peter R. Flatt

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 276 KB

english, 2002

16

Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL37) in normal mice

Nigel Irwin, Brian D. Green, Victor A. Gault, Roslyn S. Cassidy, Finbarr P.M. O’Harte, Patrick Harriott, Peter R. Flatt

Journal:

Year:

2006

Language:

english

File:

PDF, 456 KB

english, 2006

17

Synthetic Peptides Interacting with the 67-kd Laminin Receptor Can Reduce Retinal Ischemia and Inhibit Hypoxia-Induced Retinal Neovascularization

Dorota Gebarowska, Alan W. Stitt, Thomas A. Gardiner, Patrick Harriott, Brett Greer, John Nelson

Journal:

The American Journal of Pathology

Year:

2002

Language:

english

File:

PDF, 1.52 MB

english, 2002

18

Identification of potential activators of proteinase-activated receptor-2

Mark T. Fox, Patrick Harriott, Brian Walker, Stuart R. Stone

Journal:

Year:

1997

Language:

english

File:

PDF, 386 KB

english, 1997

19

Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo

Victor A Gault, Finbarr P.M O’Harte, Patrick Harriott, Peter R Flatt

Journal:

Year:

2003

Language:

english

File:

PDF, 341 KB

english, 2003

20

Toxicity of a N-terminal fragment of the non-Aß component of Alzheimer's disease amyloid

Angela M. Bodles, Brent G. Irvine, David J.S. Guthrie, Patrick Harriott

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 195 KB

english, 2000

21

A modified Tat peptide for selective intracellular delivery of macromolecules

Diarmaid J. Murphy, Brian Walker, Brett Greer, Patrick Harriott, S. Lorraine Martin

Journal:

Journal of Pharmacy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 647 KB

english, 2011

22

Soluble beta-amyloid[25–35] reversibly impairs hippocampal synaptic plasticity and spatial learning

Christian Holscher, Simon Gengler, Victor A. Gault, Patrick Harriott, Hanspeter A. Mallot

Journal:

European Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 516 KB

english, 2007

23

GIP(Lys 16 PAL) and GIP(Lys 37 PAL): Novel Long-Acting Acylated Analogues of Glucose-Dependent Insulinotropic Polypeptide with Improved Antidiabetic Potential

Irwin, Nigel, O'Harte, Finbarr P. M., Gault, Victor A., Green, Brian D., Greer, Brett, Harriott, Patrick, Bailey, Clifford J., Flatt, Peter R.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 233 KB

english, 2006

24

Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes

Gault, Victor A., Hunter, Kerry, Irwin, Nigel, Greer, Brett, Green, Brian D., Harriott, Patrick, O'Harte, Finbarr P.M., Flatt, Peter R.

Journal:

Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 314 KB

english, 2007

25

Heat transfer in packed-tube reactors

Peters, Patrick E., Schiffino, Rinaldo S., Harriott, Peter

Journal:

Industrial & Engineering Chemistry Research

Year:

1988

Language:

english

File:

PDF, 948 KB

english, 1988

26

Novel Linear Transition Metal Clusters of a Heptadentate Bis-β-diketone Ligand

Aromí, Guillem, Gamez, Patrick, Krzystek, J., Kooijman, Huub, Spek, Anthony L., MacLean, Elizabeth J., Teat, Simon J., Nowell, Harriott

Journal:

Inorganic Chemistry

Year:

2007

Language:

english

File:

PDF, 266 KB

english, 2007

27

Degradation, Insulin Secretion, and Antihyperglycemic Actions of Two Palmitate-Derivitized N -Terminal Pyroglutamyl Analogues of Glucose-Dependent Insulinotropic Polypeptide

Irwin, Nigel, Green, Brian D., Gault, Victor A., Greer, Brett, Harriott, Patrick, Bailey, Clifford J., Flatt, Peter R., O'Harte, Finbarr P. M.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 346 KB

english, 2005

28

Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37)

Irwin, Nigel, Gault, Victor A., Green, Brian D., Greer, Brett, Harriott, Patrick, Bailey, Clifford J., Flatt, Peter R., O'Harte, Finbarr P.M.

Journal:

Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 257 KB

english, 2005

29

Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice

Irwin, Nigel, Gault, Victor A., Green, Brian D., Greer, Brett, McCluskey, Jane T., Harriott, Patrick, O’Harte, Finbarr P.M., Flatt, Peter R.

Journal:

Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 240 KB

english, 2004

30

Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes

GAULT, Victor A., FLATT, Peter R., BAILEY, Clifford J., HARRIOTT, Patrick, GREER, Brett, MOONEY, Mark H., O'HARTE, Finbarr P.M.

Journal:

Biochemical Journal

Year:

2002

Language:

english

File:

PDF, 266 KB

english, 2002

31

Successful syntheses of β amyloid-(25–35)-peptide: a difficult sequence by N -(9-fluorenylmethoxycarbonyl) chemistry

Guthrie, David J. S., El-Agnaf, Omar, Harriott, Patrick, Irvine, G. Brent, Walker, Brian

Journal:

Biochemical Society Transactions

Year:

1994

Language:

english

File:

PDF, 285 KB

english, 1994

32

46 Studies on the aggregation and secondary structure of peptides derived from non-Aβ component of Alzheimer's disease amyloid

IRVINE, G. BRENT, EL-AGNAF, OMAR M. A., BODLES, ANGELA M., GUTHRIE, DAVID J. S., HARRIOTT, PATRICK

Journal:

Biochemical Society Transactions

Year:

1998

Language:

english

File:

PDF, 127 KB

english, 1998

33

Studies on toxicity of N-terminal fragments of the non-Aβ component of Alzheimer's disease amyloid

Bodles, Angela M., Guthrie, David J. S., Harriott, Patrick, Campbell, Pamela, Irvine, G. Brent

Journal:

Biochemical Society Transactions

Year:

2000

Language:

english

File:

PDF, 114 KB

english, 2000

34

Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity

Gault, Victor A., Kerr, Barry D., Harriott, Patrick, Flatt, Peter R.

Journal:

Clinical Science

Year:

2011

Language:

english

File:

PDF, 742 KB

english, 2011

35

Ontogeny of symbiont community structure in two carotenoid-rich, viviparous marine sponges: comparison of microbiomes and analysis of culturable pigmented heterotrophic bacteria

Sacristán-Soriano, Oriol, Winkler, Marina, Erwin, Patrick, Weisz, Jeremy, Harriott, Olivia, Heussler, Gary, Bauer, Emily, West Marsden, Brittany, Hill, April, Hill, Malcolm

Journal:

Environmental Microbiology Reports

Year:

2019

Language:

english

File:

PDF, 2.44 MB

english, 2019

36

Characterization of a Ligand-attenuated Binding Site on Glycoprotein IIb/IIIa

Quinn, Martin, Fullard, John, Kerrigan, Steven, Harriott, Patrick, Cox, Dermot, Fitzgerald, Desmond

Journal:

Thrombosis and Haemostasis

Year:

2002

Language:

english

File:

PDF, 144 KB

english, 2002

37

Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1

McRedmond, James P., Harriott, Patrick, Walker, Brian, Fitzgerald, Desmond J.

Journal:

Year:

2000

Language:

english

File:

PDF, 264 KB

english, 2000

38

Evaluation of the Antidiabetic and Insulin Releasing Effects of A. squamosa, Including Isolation and Characterization of Active Phytochemicals

Ansari, Prawej, Flatt, Peter R., Harriott, Patrick, Abdel-Wahab, Yasser H.A.

Journal:

Year:

2020

File:

PDF, 4.12 MB

2020

39

Anti-hyperglycaemic and insulin releasing effects of Camellia sinensis leaves and isolation and characterization of active compounds

Ansari, Prawej, Flatt, Peter R., Harriott, Patrick, Abdel-Wahab, Yasser H.A.

Journal:

British Journal Of Nutrition

Year:

2020

File:

PDF, 1.66 MB

2020

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